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A prostate biopsy is a procedure in which small samples of tissue are removed from the prostate gland and examined under a microscope to check for the presence of cancerous cells. This procedure is usually performed if there are abnormalities found in the results of other tests, such as a prostate-specific antigen (PSA) blood test or a digital rectal exam (DRE). During a prostate biopsy, a doctor will insert a thin, hollow needle through the rectum or the area between the scrotum and the anus to remove small samples of tissue from different areas of the prostate gland. The procedure is usually performed under local anesthesia, and it usually takes about 10 to 15 minutes to complete. After the biopsy, patients may experience some discomfort or pain, as well as minor bleeding from the rectum or the penis. It is important to avoid strenuous activity and sexual activity for a few days after the procedure to allow the prostate gland to heal. It is also important to discuss the risks and benefits of a prostate biopsy with a healthcare provider before undergoing the procedure. Possible risks of a prostate biopsy include bleeding, infection, and difficulty urinating. However, the procedure is generally considered safe and is an important tool for diagnosing prostate cancer.